Kratom Potentiators – What Are They and How Do They Work?

Kratom Potentiators – What Are They and How Do They Work?

How to Make Kratom Stronger? 

It’s a question we hear frequently. Despite some seriously potent veins and strains of kratom on the market (such as Maeng Da), some consumers are seeking out potentiators as a means of ‘supercharging’ their kratom.

What is a Potentiator?

In clinical terms, a potentiator is a substance that has the ability to enhance the effects of another substance. In the context of kratom, a potentiator would be used to increase the intensity, potency and/or duration of its effects.

For millennia, people around the world have been experimenting with combining various substances, consuming them together in an effort to achieve a more intense or better experience.  

Why Potentiators Are Effective With Kratom 

Since the 1600s, people have combined morphine with potentiators in an effort to increase the euphoric ‘high’ associated with the drug. Why is this relevant to kratom you ask? 

Kratom’s primary alkaloids have been shown in clinical research to act on the body’s natural opioid receptors to elicit much of its effects when consumed. Because of this similarity, consumers have sought out similar methods to intensify their experience with kratom, using many of the same potentiators as have opioid users in the past.

Are Kratom Potentiators Safe? 

We can’t offer any type of medical or health advice. That said, some potentiators (such as grapefruit juice) are known to be safe and approved for human consumption. In other cases, potentiators such as alcohol have been shown to be clinically harmful even when consumed on its own.

When combined with kratom or other medications, the combination can be dangerous, and in some cases deadly. As such, we can’t advise nor recommend their use to enhance the kratom experience, and any effort to do so should be used with extreme caution and ideally under the directive of a healthcare professional.

How do Kratom Potentiators Work? 

There are three primary mechanisms of action through which a potentiator can supercharge the effects of kratom.

1. Synergistic but Separate Effects

There may be some substances that have little to no influence over kratom metabolism in the body, but that offers its own unique physiological effects that could in some ways complement those of kratom. An example would include alcohol, and some other types of supplements and/or drugs.

2. Substances that Increase Alkaloid Concentration

Some substances may act biochemically to actually increase the concentration of kratom’s alkaloids in the bloodstream, thus increasing its effects.

3. Slowing Down or Enhancing Metabolism of Kratom

In other cases, potentiators may impact enzymes needed to metabolize and break down kratom in your body. For example, grapefruit is known to inhibit a key metabolic enzyme to increase the concentration of other substances that would otherwise be metabolized and excreted by the body. Alternatively, Cayenne pepper acts to improve absorption of kratom before processing by the liver, thus making more of the dose ‘bioavailable’ for use by the body.

What are the Best Kratom Potentiators? 

***WE DO NOT RECOMMEND NOR ENDORSE THE USE OF KRATOM POTENTIATORS DUE TO POTENTIAL HEALTH HAZARDS SOME OF WHICH MAY BE LETHAL. 

***THIS INFORMATION IS FOR EDUCATIONAL PURPOSES ONLY

Food Items as Potentiators:

  • Grapefruit juice
  • Orange juice
  • Lime juice
  • Turmeric 
  • Cayenne pepper
  • Apple cider vinegar
  • Black pepper
  • Watercress

Supplements as Potentiators:

  • Cat’s Claw
  • Caffeine 
  • Valerian Root 
  • Magnesium
  • Phenibut
  • Chamomile 

At The Kratom Connection, we remain dedicated to providing safe, effective and potent third-party lab tested kratom from farm to consumer. Ranking among the most potent of strains is Maeng Da (red, white, green and yellow varieties). While kratom potentiators may be used to stretch out or make kratom doses last longer, if pure potency and strength of effects is what users are after, a hefty dose of a strain notable for its naturally potent effects is often the better route to take.

kratom powder samples

Enjoy These Beginner Recipes for Your Kratom Powder Responsibly

We hope you enjoyed this guide covering some of the best beginner recipes for your kratom powder. When it comes to concoctions, dishes or drinks, the sky is the limit with kratom. Don’t be afraid to experiment with your own special recipes to find that perfect combination.